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Patients taking other B-vitamin supplements or multivitamin preparations should inform their prescribing provider, as evaluation for potential additive effects or imbalances may be appropriate

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However, the combined effect of multiple BDNF-boosting compounds on total TrkB activation has not been systematically studied, so conservative dosing is advisable

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A review of age-related dehydroepiandrosterone decline and its association with well-known geriatric syndromes: is treatment beneficial

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